Background Chronic kidney disease (CKD) is a major global public health problem, being closely connected to cardiovascular disease. CKD involves an elevated thromboembolic risk and requires anticoag…
Archivi categoria: farmaci
Anticoagulation in chronic kidney disease: from guidelines to clinical practice – Aursulesei – 2019 – Clinical Cardiology – Wiley Online Library
Hospital based programs dedicated to improving antibiotic use, commonly referred to as “Antimicrobial Stewardship Programs” (ASPs), can both optimize the treatment of infections and reduce a…
Risk Factors and Outcomes Associated With Treatment of Asymptomatic Bacteriuria in Hospitalized Patients | UTI JAMA Network
This cohort study examines the outcomes of treatment of asymptomatic bacteriuria in hospitalized patients.
Abbassare il c-Ldl quanto più possibile, soprattutto nei soggetti ad alto rischio cardiovascolare. Questo il messaggio chiave delle nuove linee guida…
Si è svolta ieri in AIFA la presentazione del Rapporto Nazionale 2018 “L’Uso dei Farmaci in Italia”: sono intervenuti Luca Li Bassi, Francesco Trotta, Silvio Garattini, Armando Bartolazzi.
Association of Acute Increases in Plasma Creatinine after Renin-Angiotensin Blockade with Subsequent Outcomes | American Society of Nephrology
Background and objectives Data from observational and interventional studies provide discordant results regarding the relationship between creatinine increase after renin-angiotensin system inhibition (RASi) and adverse outcomes. We compared health outcomes among patients with different categories of increase in creatinine upon initiation of RASi in a large population-based cohort. Design, setting, participants, & measurements We performed a retrospective analysis of the Stockholm CREAtinine Measurements database, which contains complete information on diagnoses, medication dispensation claims, and laboratory test results for all Stockholm citizens accessing health care. Included were 31,951 adults initiating RASi during 2007–2011 with available pre- and postinitiation creatinine monitoring. Multivariable Cox regression was used to compare mortality, cardiovascular and ESKD events among individuals with different ranges of creatinine increases within 2 months after starting treatment. Results In a median follow-up of 3.5 years, acute increases in creatinine were associated with mortality (3202 events) in a graded manner: compared with creatinine increases <10%, a 10%–19% increase